Xolotl Exercise 1

Exercise One: Single Channel Activity

Watch me first

Make sure initial conditions are correct

Type runXoltolRun in the Matlab command window.
Select Exercise One button.
Set initial conditions:
- Number of Inhibitory Channels: 1
- Number of Excitatory Channels: 0

Please complete Exercise One:

After you run Exercise One, you should see a plot that shows brief downward deflections over the course of a two second recording.

Each downward deflection represents the change in the neuron's membrane potential during a brief opening of an ion channel.

1. What is the neuron's membrane potential prior to channel opening?

7. For this question, re-run Exercise 1 (runXolotlRun), but now add an additional inhibitory channel (for a total of two inhibitory channels).

10. For this question, re-run Exercise 1 (runXolotlRun), but now run the simulation with a total of 50 inhibitory channels and a total of 50 excitatory channels.

After you run Exercise One, you should see a plot that shows brief downward deflections over the course of a two second recording.

Each downward deflection represents the change in the neuron's membrane potential during a brief opening of an ion channel.

1. What is the neuron's membrane potential prior to channel opening?

7. For this question, re-run Exercise 1 (runXolotlRun), but now add an additional inhibitory channel (for a total of two inhibitory channels).

10. For this question, re-run Exercise 1 (runXolotlRun), but now run the simulation with a total of 50 inhibitory channels and a total of 50 excitatory channels.