Hodgkin & Huxley Model The Action Potential

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Outline

1. Ion Channel Diversity

2. Classical Description of Ion Channels

3. Biophysics of squid giant axon

   • Summary of the experimental model

   • Brief reminder of voltage-clamping technique

   • Empirical description of action potential

   • Summary of Hodgkin-Huxley models

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Slides

• Ionic Basis of Neuronal Excitability

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Reading For Next Class

• Structures of closed and open states of a voltage-gated sodium channel

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Background Papers

• 1952a: Measurement Of Current-Voltage Relations In The Membrane Of The Giant Axon Of Loligo. HODGKIN AL, HUXLEY AF, KATZ B. J Physiol. 1952 Apr;116(4):424-48

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• 1952b: Currents Carried By Sodium And Potassium Ions Through The Membrane Of The Giant Axon Of Loligo. HODGKIN AL, HUXLEY AF. J Physiol. 1952 Apr;116(4):449-72.

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• 1952c: The Components Of Membrane Conductance In The Giant Axon Of Loligo. HODGKIN AL, HUXLEY AF. J Physiol. 1952 Apr;116(4):473-96

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• 1952d: The Dual Effect Of Membrane Potential On Sodium Conductance In The Giant Axon Of Loligo. HODGKIN AL, HUXLEY AF. J Physiol. 1952 Apr;116(4):497-506

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• 1952e: A Quantitative Description Of Membrane Current And Its Application To Conduction And Excitation In Nerve. HODGKIN AL, HUXLEY AF. J Physiol. 1952 Aug;117(4):500-44

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Book Chapters

• Johnson & Wu: Hodgkin and Huxley's Analysis of the Squid Giant Axon

• Hille: Classical Biophysics of the Squid Giant Axon

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Web Resources

• The Hodgkin-Huxley Model for the Generation of Action Potentials