Microcircuits & Plasticity

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Outline

1. Diverse connections between two neurons

2. Definition of a microcircuit

3. Connections are plastic

   • Long-Term Plasticity

   • Short-Term Plasticity

   • Spike Timing-Dependent Plasticity

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Slides

• Hippocampus & Plasticity

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Reading For Class

• Kand el: Chapters 67

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Extra Reading

• Costa et al., 2017: Functional consequences of pre- and postsynaptic expression of synaptic plasticity

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• Feldman, 2012: The Spike-Timing Dependence of Plasticity

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• Lisman, 2017: Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)

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• ​vanStrien et al., 2009: The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network

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• Muller & Remy, 2017: Septo-hippocampal interaction

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• Fuhrmann et al., 2015: Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit

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• Dragoi & Buzsaki, 2007: Temporal Encoding of Place Sequences by Hippocampal Cell Assemblies

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• Amaral et al., 2007: The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

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• Yassa & Stark, 2011: Pattern separation in the hippocampus

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• Yu et al., 2017: Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility

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• Sun et al., 2020: Hippocampal neurons represent events as transferable units of experience​

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• Girardeau et al., 2009: Selective suppression of hippocampal ripples impairs spatial memory