Microcircuits & Plasticity

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Outline

1. Diverse connections between two neurons

2. Definition of a microcircuit

3. Connections are plastic

   • Long-Term Plasticity

   • Short-Term Plasticity

   • Spike Timing-Dependent Plasticity

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Slides

• Microcircuits & Plasticity

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Reading For Class

• Kandel: Chapters 67

• Handbook of Brain Microcircuits: Chapter Two (Douglas & Martin)

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Extra Reading

• Costa et al., 2017: Functional consequences of pre- and postsynaptic expression of synaptic plasticity

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• Feldman, 2012: The Spike-Timing Dependence of Plasticity

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• Lisman, 2017: Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)

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• Memory formation depends on both synapsespecific modifications of synaptic strength and cell-specific increases in excitability

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• Causes and consequences of representational drift